Asenapine discontinued in the UK: what you need to know
- Posted: 15 May 2026
Some people in the bipolar community may be aware that asenapine tablets have been discontinued in the UK. This is reportedly due to low usage.
The affected products are asenapine (Sycrest®) 5mg and 10mg sublingual tablets.
Asenapine is an antipsychotic medication sometimes prescribed to help manage the symptoms of bipolar I (acute mania or mixed episodes), and other severe mental illnesses (SMIs).
There is no equivalent medication available as asenapine has its own chemical group, meaning some people may have already tried alternative medicines to manage their bipolar symptoms.
While Bipolar UK investigates the discontinuation of asenapine, and wider medication shortages (see below), anyone taking it is advised to continue to do so as prescribed. If you haven’t been contacted, please reach out to your doctor ss soon as possible about your alternative options and a safe transition plan.
It is strongly advised not to stop taking antipsychotics suddenly, as this can lead to acute withdrawal symptoms or rapid relapse. Instead, it is recommended to stop asenapine gradually under close supervision of a mental health specialist to avoid risk.
If you’re feeling worried or anxious you can access practical information, advice and support via our peer support services. For urgent help, visit our crisis support page.
What are antipsychotic medications?
Antipsychotics are a type of psychiatric medication used to treat SMIs like bipolar.
While antipsychotic medications don't cure psychosis, they can help to manage many bipolar symptoms, including:
- delusions and hallucinations, such as paranoia and seeing or hearing things that aren’t there
- anxiety and irritability
- hypomania and mania
The aim of antipsychotics is to help people with bipolar feel more stable. Taking antipsychotics can also reduce the risk of a relapse where symptoms return.
People find some types of antipsychotic work better than others for their symptoms.
Find out more about the different types of antipsychotics.
Wider medication shortages
Bipolar UK are also aware of other serious medication shortages that are affecting people living with bipolar, including lamotrigine. We are actively working with experts to investigate the shortages and will update the community as we learn more in the coming weeks.
If you are concerned about your medication, please contact your healthcare team to discuss your options.
